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1

Anti-cancer activities of novel D-ring modified 2-substituted estrogen-3-O-sulfamates

Mathew P. Leese, Bertrand Leblond, Simon P. Newman, Atul Purohit, Michael J. Reed, Barry V.L. Potter

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2005

Language:

english

File:

PDF, 302 KB

english, 2005

2

ChemInform Abstract: Palladium-Catalyzed Coupling Reactions Using Guanidinium Phosphine Complexes on Glass Beads.

Mathew P. Leese, Jonathan M. J. Williams

Journal:

Year:

2000

File:

PDF, 32 KB

2000

3

ChemInform Abstract: A Survey of Suitable Protecting Groups for the Synthesis of Hydroxylamines by Mitsunobu Reactions.

David W. Knight, Mathew P. Leese

Journal:

Year:

2001

File:

PDF, 29 KB

2001

4

ChemInform Abstract: The Synthesis of N-Hydroxyisoindolines by Reverse-Cope Chemistry.

David W. Knight, Mathew P. Leese, Norbert De Kimpe

Journal:

Year:

2001

File:

PDF, 28 KB

2001

5

2-Alkylsulfanyl Estrogen Derivatives: Synthesis of a Novel Class of Multi-Targeted Antitumor Agents.

Mathew P. Leese, Simon P. Newman, Atul Purohit, Michael J. Reed, Barry V. L. Potter

Journal:

Year:

2004

File:

PDF, 33 KB

2004

6

Inhibition of in vitro angiogenesis by 2-methoxy- and 2-ethyl-estrogen sulfamates

Simon P. Newman, Mathew P. Leese, Atul Purohit, David R.C. James, Catherine E. Rennie, Barry V.L. Potter, Michael J. Reed

Journal:

International Journal of Cancer

Year:

2004

Language:

english

File:

PDF, 232 KB

english, 2004

7

Inhibition of MDA-MB-231 cell cycle progression and cell proliferation by C-2-substituted oestradiol mono- and bis-3-O-sulphamates

Bindumalini Raobaikady, Michael J. Reed, Mathew P. Leese, Barry V.L. Potter, Atul Purohit

Journal:

International Journal of Cancer

Year:

2005

Language:

english

File:

PDF, 485 KB

english, 2005

8

2-Alkylsulfanyl estrogen derivatives: synthesis of a novel class of multi-targeted anti-tumour agents

Mathew P. Leese, Simon P. Newman, Atul Purohit, Michael J. Reed, Barry V.L. Potter

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 250 KB

english, 2004

9

The synthesis of N-hydroxyisoindolines by reverse-Cope chemistry

David W Knight, Mathew P Leese, Norbert De Kimpe

Journal:

Tetrahedron Letters

Year:

2001

Language:

english

File:

PDF, 71 KB

english, 2001

10

A survey of suitable protecting groups for the synthesis of hydroxylamines by Mitsunobu reactions

David W Knight, Mathew P Leese

Journal:

Tetrahedron Letters

Year:

2001

Language:

english

File:

PDF, 60 KB

english, 2001

11

Allene formation by the reaction of olefins with propargyl silyl ethers mediated by a zirconocene complex

Tamotsu Takahashi, Ryuichiro Hara, Shouquan Huo, Yasuyuki Ura, Mathew P. Leese, Noriyuki Suzuki

Journal:

Tetrahedron Letters

Year:

1997

Language:

english

File:

PDF, 197 KB

english, 1997

12

Collaborative community based care for people and their families living with schizophrenia in India: protocol for a randomised controlled trial

Sudipto Chatterjee, Morven Leese, Mirja Koschorke, Paul McCrone, Smita Naik, Sujit John, Hamid Dabholkar, Kimberley Goldsmith, Madhumitha Balaji, Mathew Varghese, Rangaswamy Thara, Vikram Patel, Graha

Journal:

Year:

2011

Language:

english

File:

PDF, 347 KB

english, 2011

13

2-MeOE2bisMATE and 2-EtE2bisMATE induce cell cycle arrest and apoptosis in breast cancer xenografts as shown by a novel ex

Paul A. Foster, Yaik T. Ho, Simon P. Newman, Philip G. Kasprzyk, Mathew P. Leese, Barry V. L. Potter, Michael J. Reed, Atul Purohit

Journal:

Breast Cancer Research and Treatment

Year:

2008

Language:

english

File:

PDF, 483 KB

english, 2008

14

A new, stereoselective approach to pyrrolidine-N-oxides by sequential condensation of sulfones with nitrones and reverse-cope elimination

Andrew R. Wheildon, David W. Knight, Mathew P. Leese

Journal:

Tetrahedron Letters

Year:

1997

Language:

english

File:

PDF, 193 KB

english, 1997

15

Chimeric microtubule disruptors

Leese, Mathew P., Jourdan, Fabrice, Kimberley, Meriel R., Cozier, Gyles E., Thiyagarajan, Nethaji, Stengel, Chloe, Regis-Lydi, Sandra, Foster, Paul A., Newman, Simon P., Acharya, K. Ravi

Journal:

Chemical Communications

Year:

2010

Language:

english

File:

PDF, 1.14 MB

english, 2010

16

2-Difluoromethyloestrone 3-O-sulphamate, a highly potent steroid sulphatase inhibitor

Julie E Reed, L.W Lawrence Woo, James J Robinson, Bertrand Leblond, Mathew P Leese, Atul Purohit, Michael J Reed, Barry V.L Potter

Journal:

Biochemical and Biophysical Research Communications

Year:

2004

Language:

english

File:

PDF, 256 KB

english, 2004

17

Inhibition of MCF-7 breast cancer cell proliferation and in vivo steroid sulphatase activity by 2-methoxyoestradiol-bis-sulphamate

Bindumalini Raobaikady, Atul Purohit, Surinder K. Chander, L.W.Lawrence Woo, Mathew P. Leese, Barry V.L. Potter, Michael J. Reed

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2003

Language:

english

File:

PDF, 195 KB

english, 2003

18

Structure–Activity Relationships of C-17-Substituted Estratriene-3- O -sulfamates as Anticancer Agents

Jourdan, Fabrice, Leese, Mathew P., Dohle, Wolfgang, Ferrandis, Eric, Newman, Simon P., Chander, Surinder, Purohit, Atul, Potter, Barry V. L.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 2.62 MB

english, 2011

19

2-Substituted Estradiol Bis-sulfamates, Multitargeted Antitumor Agents: Synthesis, In Vitro SAR, Protein Crystallography, and In Vivo Activity †

Leese, Mathew P., Leblond, Bertrand, Smith, Andrew, Newman, Simon P., Di Fiore, Anna, De Simone, Giuseppina, Supuran, Claudiu T., Purohit, Atul, Reed, Michael J., Potter, Barry V. L.

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 411 KB

english, 2006

20

Effects of C-17 heterocyclic substituents on the anticancer activity of 2-ethylestra-1,3,5(10)-triene-3-O-sulfamates: synthesis, in vitro evaluation and computational modelling

Jourdan, Fabrice, Bubert, Christian, Leese, Mathew P., Smith, Andrew, Ferrandis, Eric, Regis-Lydi, Sandra, Newman, Simon P., Purohit, Atul, Reed, Michael J., Potter, Barry V. L.

Journal:

Organic & Biomolecular Chemistry

Year:

2008

Language:

english

File:

PDF, 385 KB

english, 2008

21

3,17-Disubstituted 2-Alkylestra-1,3,5(10)-trien-3-ol Derivatives: Synthesis, In Vitro and In Vivo Anticancer Activity

Bubert, Christian, Leese, Mathew P., Mahon, Mary F., Ferrandis, Eric, Regis-Lydi, Sandra, Kasprzyk, Philip G., Newman, Simon P., Ho, Yaik T., Purohit, Atul, Reed, Michael J., Potter, Barry V. L.

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 366 KB

english, 2007

22

Synthesis, Antitubulin, and Antiproliferative SAR of Analogues of 2-Methoxyestradiol-3,17- O , O -bis-sulfamate

Jourdan, Fabrice, Leese, Mathew P., Dohle, Wolfgang, Hamel, Ernest, Ferrandis, Eric, Newman, Simon P., Purohit, Atul, Reed, Michael J., Potter, Barry V. L.

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 1.13 MB

english, 2010

23

Tetrahydroisoquinolinone-Based Steroidomimetic and Chimeric Microtubule Disruptors

Leese, Mathew P., Jourdan, Fabrice L., Major, Meriel R., Dohle, Wolfgang, Hamel, Ernest, Ferrandis, Eric, Fiore, Ann, Kasprzyk, Philip G., Potter, Barry V. L.

Journal:

Year:

2014

Language:

english

File:

PDF, 927 KB

english, 2014

24

Synthesis, Anti-tubulin and Antiproliferative SAR of Steroidomimetic Dihydroisoquinolinones

Leese, Mathew P., Jourdan, Fabrice L., Major, Meriel R., Dohle, Wolfgang, Thomas, Mark P., Hamel, Ernest, Ferrandis, Eric, Mahon, Mary F., Newman, Simon P., Purohit, Atul, Potter, Barry V. L.

Journal:

Year:

2014

Language:

english

File:

PDF, 761 KB

english, 2014

25

Synthesis, Antitubulin, and Antiproliferative SAR of C3/C1-Substituted Tetrahydroisoquinolines

Dohle, Wolfgang, Leese, Mathew P., Jourdan, Fabrice L., Major, Meriel R., Bai, Ruoli, Hamel, Ernest, Ferrandis, Eric, Kasprzyk, Philip G., Fiore, Ann, Newman, Simon P., Purohit, Atul, Potter, Barry V.

Journal:

Year:

2014

Language:

english

File:

PDF, 671 KB

english, 2014

26

Structures of Human Carbonic Anhydrase II/Inhibitor Complexes Reveal a Second Binding Site for Steroidal and Nonsteroidal Inhibitors ,

Cozier, Gyles E., Leese, Mathew P., Lloyd, Matthew D., Baker, Matthew D., Thiyagarajan, Nethaji, Acharya, K. Ravi, Potter, Barry V. L.

Journal:

Year:

2010

Language:

english

File:

PDF, 5.81 MB

english, 2010

27

StructureâActivity Relationships of C-17 Cyano-Substituted Estratrienes as Anticancer Agents â

Leese, Mathew P., Jourdan, Fabrice L., Gaukroger, Keira, Mahon, Mary F., Newman, Simon P., Foster, Paul A., Stengel, Chloe, Regis-Lydi, Sandra, Ferrandis, Eric, Fiore, Anna Di, De Simone, Giuseppina,

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 1.16 MB

english, 2008

28

Transition metal catalysed reactions using glass bead technology

Anson, Michael S., Leese, Mathew P., Tonks, Louise, Williams, Jonathan M. J.

Journal:

Journal of the Chemical Society Dalton Transactions

Year:

1998

Language:

english

File:

PDF, 524 KB

english, 1998

29

A-Ring-Substituted Estrogen-3- O -sulfamates: Potent Multitargeted Anticancer Agents

Leese, Mathew P., Hejaz, Hatem A. M., Mahon, Mary F., Newman, Simon P., Purohit, Atul, Reed, Michael J., Potter, Barry V. L.

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 219 KB

english, 2005

30

Steroidomimetic Tetrahydroisoquinolines for the Design of New Microtubule Disruptors

Leese, Mathew P., Jourdan, Fabrice, Dohle, Wolfgang, Kimberley, Meriel R., Thomas, Mark P., Bai, Ruoli, Hamel, Ernest, Ferrandis, Eric, Potter, Barry V. L.

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 978 KB

english, 2012

31

Cover Picture: Tetrahydroisoquinolinone-Based Steroidomimetic and Chimeric Microtubule Disruptors (ChemMedChem 1/2014)

Leese, Mathew P., Jourdan, Fabrice L., Major, Meriel R., Dohle, Wolfgang, Hamel, Ernest, Ferrandis, Eric, Fiore, Ann, Kasprzyk, Philip G., Potter, Barry V. L.

Journal:

Year:

2014

Language:

english

File:

PDF, 1.29 MB

english, 2014

32

Optimisation of Tetrahydroisoquinoline-Based Chimeric Microtubule Disruptors

Dohle, Wolfgang, Leese, Mathew P., Jourdan, Fabrice L., Chapman, Christopher J., Hamel, Ernest, Ferrandis, Eric, Potter, Barry V. L.

Journal:

Year:

2014

Language:

english

File:

PDF, 445 KB

english, 2014

33

Erratum to: Pharmacokinetic Evaluations of the Co-Administrations of Vandetanib and Metformin, Digoxin, Midazolam, Omeprazole or Ranitidine

Johansson, Susanne, Read, Jessica, Oliver, Stuart, Steinberg, Mark, Li, Yan, Lisbon, Eleanor, Mathews, David, Leese, Philip T., Martin, Paul

Journal:

Clinical Pharmacokinetics

Year:

2014

Language:

english

File:

PDF, 137 KB

english, 2014

34

Literature

Caird, G.B., Baelz, P., Hick, J., Mayor, S., Davies, J.G., Greeves, F., Ward, M., Eddy, G. T., Leese, K., Mathews, H.F., Searle, J. D.

Journal:

The Expository Times

Year:

1969

Language:

english

File:

PDF, 774 KB

english, 1969

35

Palladium Catalysed Coupling Reactions using Guanidinium Phosphine Complexes on Glass Beads

Leese, Mathew P., Williams, Jonathan M. J.

Journal:

Year:

1999

Language:

english

File:

PDF, 165 KB

english, 1999

36

Targeted NF1 cancer therapeutics with multiple modes of action: small molecule hormone-like agents resembling the natural anticancer metabolite, 2-methoxyoestradiol

Shen, Yu-chi, Upadhyayula, Ravi, Cevallos, Stephanie, Messick, Ryan J, Hsia, Tammy, Leese, Mathew P, Jewett, Douglas M, Ferrer-Torres, Daysha, Roth, Therese M, Dohle, Wolfgang, Potter, Barry V L, Bara

Journal:

British Journal of Cancer

Year:

2015

Language:

english

File:

PDF, 2.11 MB

english, 2015

37

A comparison of two orally bioavailable anti-cancer agents, IRC-110160 and STX140

Foster, Paul a., Stengel, C., Ali, Tauhid, Leese, Mathew P., Potter, Barry V L, Reed, Michael J., Purohit, Atul, Newman, Simon P.

Journal:

Anticancer research

Year:

2008

Language:

english

File:

PDF, 393 KB

english, 2008

38

Accessing simply-substituted 4-hydroxytetrahydroisoquinolines via Pomeranz–Fritsch–Bobbitt reaction with non-activated and moderately-activated systems

Mottinelli, Marco, Leese, Mathew P, Potter, Barry V L

Journal:

Beilstein Journal of Organic Chemistry

Year:

2017

Language:

english

File:

PDF, 319 KB

english, 2017

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